The quail and chicken intestine have sialyl-galactose sugar chains responsible for the binding of influenza A viruses to human type receptors
Identifieur interne : 001398 ( Main/Exploration ); précédent : 001397; suivant : 001399The quail and chicken intestine have sialyl-galactose sugar chains responsible for the binding of influenza A viruses to human type receptors
Auteurs : Chao-Tan Guo [République populaire de Chine, Japon] ; Noriko Takahashi [Japon] ; Hirokazu Yagi [Japon] ; Koichi Kato [Japon] ; Tadanobu Takahashi [Japon] ; Shuang-Qin Yi [Japon] ; Yong Chen [République populaire de Chine] ; Toshihiro Ito ; Koichi Otsuki [Japon] ; Hiroshi Kida [Japon] ; Yoshihiro Kawaoka [Japon, États-Unis] ; Kazuya I-P Jwa Hidari [Japon] ; Daisei Miyamoto [Japon] ; Takashi Suzuki [Japon] ; Yasuo Suzuki [Japon]Source :
- Glycobiology [ 0959-6658 ] ; 2007.
Abstract
The receptor specificity of influenza viruses is one factor that allows avian influenza viruses to cross the species barrier. The recent transmissions of avian H5N1 and H9N2 influenza viruses from chickens and/or quails to humans indicate that avian influenza viruses can directly infect humans without an intermediate host, such as pigs. In this study, we used two strains of influenza A virus (A/PR/8/34, which preferentially binds to an avian-type receptor, and A/Memphis/1/71, which preferentially binds to a human-type receptor) to probe the receptor specificities in host cells. Epithelial cells of both quail and chicken intestines (colons) could bind both avian- and human-type viruses. Infected cultured quail colon cells expressed viral protein and allowed replication of the virus strain A/PR/8/34 or A/Memphis/1/71. To understand the molecular basis of these phenomena, we further investigated the abundance of sialic acid (Sia) linked to galactose (Gal) by the α2-3 linkage (Siaα2‐3Gal) and Siaα2-6Gal in host cells. In glycoprotein and glycolipid fractions from quail and chicken colon epithelial cells, there were some bound components of Sia–Gal linkage-specific lectins, Maackia amurensis agglutinin (specific for Siaα2‐3 Gal) and Sambucus nigra agglutinin (specific for Siaα2-6Gal), indicating that both Siaα2–3Gal and Siaα2-6Gal exist in quail and chicken colon cells. Furthermore, we demonstrated by fluorescence high-performance liquid chromatography (HPLC) analysis that 5-N-acetylneuraminic acid was the main molecular species of Sia, and we demonstrated by multi-dimensional HPLC mapping and matrix-assisted laser desorption/ionization time-of-flight mass spectrometry analysis that bi-antennary complex-type glycans α2-6 sialylated at the terminal Gal residue(s) are major (more than 79%) sialyl N-glycans expressed by intestinal epithelial tissues in both the chicken and quail. Taken together, these results indicate that quails and chickens have molecular characterization as potential intermediate hosts for avian influenza virus transmission to humans and could generate new influenza viruses with pandemic potential.
Url:
DOI: 10.1093/glycob/cwm038
Affiliations:
- Japon, République populaire de Chine, États-Unis
- Région de Kantō, Wisconsin, Zhejiang
- Hangzhou, Madison (Wisconsin), Tokyo
- Université de Tokyo, Université du Wisconsin à Madison
Links toward previous steps (curation, corpus...)
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- to stream Istex, to step Curation: 001561
- to stream Istex, to step Checkpoint: 000380
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Le document en format XML
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Ito</name><affiliation><wicri:noCountry code="no comma">Departments of Veterinary Public Health and</wicri:noCountry></affiliation></author><author><name sortKey="Otsuki, Koichi" sort="Otsuki, Koichi" uniqKey="Otsuki K" first="Koichi" last="Otsuki">Koichi Otsuki</name><affiliation wicri:level="1"><country xml:lang="fr">Japon</country><wicri:regionArea>Veterinary Microbiology, Faculty of Agriculture, Tottori University, Tottori-shi, Tottori 680-8553</wicri:regionArea><wicri:noRegion>Tottori 680-8553</wicri:noRegion></affiliation></author><author><name sortKey="Kida, Hiroshi" sort="Kida, Hiroshi" uniqKey="Kida H" first="Hiroshi" last="Kida">Hiroshi Kida</name><affiliation wicri:level="1"><country xml:lang="fr">Japon</country><wicri:regionArea>Laboratory of Microbiology, Department of Disease Control, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo 060-0818</wicri:regionArea><wicri:noRegion>Sapporo 060-0818</wicri:noRegion></affiliation></author><author><name sortKey="Kawaoka, Yoshihiro" sort="Kawaoka, Yoshihiro" uniqKey="Kawaoka Y" first="Yoshihiro" last="Kawaoka">Yoshihiro Kawaoka</name><affiliation wicri:level="1"><country xml:lang="fr">Japon</country><wicri:regionArea>CREST, Japan Science and Technology Agency, 4-1-8 Honcho, Kawaguchi</wicri:regionArea><wicri:noRegion>Kawaguchi</wicri:noRegion></affiliation><affiliation wicri:level="4"><country xml:lang="fr">Japon</country><wicri:regionArea>Division of Virology, Department of Microbiology and Immunology, Institute of Medical Science, University of Tokyo, Tokyo 108-8639</wicri:regionArea><placeName><settlement type="city">Tokyo</settlement><region type="région">Région de Kantō</region></placeName><orgName type="university">Université de Tokyo</orgName><placeName><settlement type="city">Tokyo</settlement><region type="province">Région de Kantō</region></placeName><placeName><settlement type="city">Madison (Wisconsin)</settlement><region type="state">Wisconsin</region></placeName><orgName type="university" n="3">Université du Wisconsin à Madison</orgName></affiliation><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Wisconsin</region></placeName><wicri:cityArea>Department of Pathobiological Sciences, School of Veterinary Medicine, University of Wisconsin, Madison</wicri:cityArea><placeName><settlement type="city">Madison (Wisconsin)</settlement><region type="state">Wisconsin</region></placeName><orgName type="university" n="3">Université du Wisconsin à Madison</orgName></affiliation></author><author><name sortKey="Hidari, Kazuya I P Jwa" sort="Hidari, Kazuya I P Jwa" uniqKey="Hidari K" first="Kazuya I-P Jwa" last="Hidari">Kazuya I-P Jwa Hidari</name><affiliation wicri:level="1"><country xml:lang="fr">Japon</country><wicri:regionArea>CREST, Japan Science and Technology Agency, 4-1-8 Honcho, Kawaguchi</wicri:regionArea><wicri:noRegion>Kawaguchi</wicri:noRegion></affiliation><affiliation wicri:level="1"><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Biochemistry, University of Shizuoka, School of Pharmaceutical Sciences, Suruga-ku, Shizuoka 422-8526</wicri:regionArea><wicri:noRegion>Shizuoka 422-8526</wicri:noRegion></affiliation></author><author><name sortKey="Miyamoto, Daisei" sort="Miyamoto, Daisei" uniqKey="Miyamoto D" first="Daisei" last="Miyamoto">Daisei Miyamoto</name><affiliation wicri:level="1"><country xml:lang="fr">Japon</country><wicri:regionArea>CREST, Japan Science and Technology Agency, 4-1-8 Honcho, Kawaguchi</wicri:regionArea><wicri:noRegion>Kawaguchi</wicri:noRegion></affiliation><affiliation wicri:level="1"><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Biochemistry, University of Shizuoka, School of Pharmaceutical Sciences, Suruga-ku, Shizuoka 422-8526</wicri:regionArea><wicri:noRegion>Shizuoka 422-8526</wicri:noRegion></affiliation></author><author><name sortKey="Suzuki, Takashi" sort="Suzuki, Takashi" uniqKey="Suzuki T" first="Takashi" last="Suzuki">Takashi Suzuki</name><affiliation wicri:level="1"><country xml:lang="fr">Japon</country><wicri:regionArea>CREST, Japan Science and Technology Agency, 4-1-8 Honcho, Kawaguchi</wicri:regionArea><wicri:noRegion>Kawaguchi</wicri:noRegion></affiliation><affiliation wicri:level="1"><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Biochemistry, University of Shizuoka, School of Pharmaceutical Sciences, Suruga-ku, Shizuoka 422-8526</wicri:regionArea><wicri:noRegion>Shizuoka 422-8526</wicri:noRegion></affiliation></author><author><name sortKey="Suzuki, Yasuo" sort="Suzuki, Yasuo" uniqKey="Suzuki Y" first="Yasuo" last="Suzuki">Yasuo Suzuki</name><affiliation wicri:level="1"><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Biomedical Sciences, College of Life and Health Sciences, Chubu University, 11200 Matsumoto-cho, Kasugai-shi, Aichi 487-8501</wicri:regionArea><wicri:noRegion>Aichi 487-8501</wicri:noRegion></affiliation><affiliation wicri:level="1"><country xml:lang="fr">Japon</country><wicri:regionArea>CREST, Japan Science and Technology Agency, 4-1-8 Honcho, Kawaguchi</wicri:regionArea><wicri:noRegion>Kawaguchi</wicri:noRegion></affiliation><affiliation wicri:level="1"><country wicri:rule="url">Japon</country></affiliation><affiliation wicri:level="1"><country wicri:rule="url">Japon</country></affiliation></author></analytic><monogr></monogr><series><title level="j" type="main">Glycobiology</title><idno type="ISSN">0959-6658</idno><idno type="eISSN">1460-2423</idno><imprint><publisher>Oxford University Press</publisher><date when="2007-07">2007</date><date type="e-published" when="2007-03-27">2007</date><biblScope unit="vol">17</biblScope><biblScope unit="issue">7</biblScope><biblScope unit="page" from="713">713</biblScope><biblScope unit="page" to="724">724</biblScope></imprint><idno type="ISSN">0959-6658</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0959-6658</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract">The receptor specificity of influenza viruses is one factor that allows avian influenza viruses to cross the species barrier. The recent transmissions of avian H5N1 and H9N2 influenza viruses from chickens and/or quails to humans indicate that avian influenza viruses can directly infect humans without an intermediate host, such as pigs. In this study, we used two strains of influenza A virus (A/PR/8/34, which preferentially binds to an avian-type receptor, and A/Memphis/1/71, which preferentially binds to a human-type receptor) to probe the receptor specificities in host cells. Epithelial cells of both quail and chicken intestines (colons) could bind both avian- and human-type viruses. Infected cultured quail colon cells expressed viral protein and allowed replication of the virus strain A/PR/8/34 or A/Memphis/1/71. To understand the molecular basis of these phenomena, we further investigated the abundance of sialic acid (Sia) linked to galactose (Gal) by the α2-3 linkage (Siaα2‐3Gal) and Siaα2-6Gal in host cells. In glycoprotein and glycolipid fractions from quail and chicken colon epithelial cells, there were some bound components of Sia–Gal linkage-specific lectins, Maackia amurensis agglutinin (specific for Siaα2‐3 Gal) and Sambucus nigra agglutinin (specific for Siaα2-6Gal), indicating that both Siaα2–3Gal and Siaα2-6Gal exist in quail and chicken colon cells. Furthermore, we demonstrated by fluorescence high-performance liquid chromatography (HPLC) analysis that 5-N-acetylneuraminic acid was the main molecular species of Sia, and we demonstrated by multi-dimensional HPLC mapping and matrix-assisted laser desorption/ionization time-of-flight mass spectrometry analysis that bi-antennary complex-type glycans α2-6 sialylated at the terminal Gal residue(s) are major (more than 79%) sialyl N-glycans expressed by intestinal epithelial tissues in both the chicken and quail. Taken together, these results indicate that quails and chickens have molecular characterization as potential intermediate hosts for avian influenza virus transmission to humans and could generate new influenza viruses with pandemic potential.</div></front></TEI><affiliations><list><country><li>Japon</li><li>République populaire de Chine</li><li>États-Unis</li></country><region><li>Région de Kantō</li><li>Wisconsin</li><li>Zhejiang</li></region><settlement><li>Hangzhou</li><li>Madison (Wisconsin)</li><li>Tokyo</li></settlement><orgName><li>Université de Tokyo</li><li>Université du Wisconsin à Madison</li></orgName></list><tree><noCountry><name sortKey="Ito, Toshihiro" sort="Ito, Toshihiro" uniqKey="Ito T" first="Toshihiro" last="Ito">Toshihiro Ito</name></noCountry><country name="République populaire de Chine"><region name="Zhejiang"><name sortKey="Guo, Chao Tan" sort="Guo, Chao Tan" uniqKey="Guo C" first="Chao-Tan" last="Guo">Chao-Tan Guo</name></region><name sortKey="Chen, Yong" sort="Chen, Yong" uniqKey="Chen Y" first="Yong" last="Chen">Yong Chen</name></country><country name="Japon"><noRegion><name sortKey="Guo, Chao Tan" sort="Guo, Chao Tan" uniqKey="Guo C" first="Chao-Tan" last="Guo">Chao-Tan Guo</name></noRegion><name sortKey="Guo, Chao Tan" sort="Guo, Chao Tan" uniqKey="Guo C" first="Chao-Tan" last="Guo">Chao-Tan Guo</name><name sortKey="Hidari, Kazuya I P Jwa" sort="Hidari, Kazuya I P Jwa" uniqKey="Hidari K" first="Kazuya I-P Jwa" last="Hidari">Kazuya I-P Jwa Hidari</name><name sortKey="Hidari, Kazuya I P Jwa" sort="Hidari, Kazuya I P Jwa" uniqKey="Hidari K" first="Kazuya I-P Jwa" last="Hidari">Kazuya I-P Jwa Hidari</name><name sortKey="Kato, Koichi" sort="Kato, Koichi" uniqKey="Kato K" first="Koichi" last="Kato">Koichi Kato</name><name sortKey="Kato, Koichi" sort="Kato, Koichi" uniqKey="Kato K" first="Koichi" last="Kato">Koichi Kato</name><name sortKey="Kato, Koichi" sort="Kato, Koichi" uniqKey="Kato K" first="Koichi" last="Kato">Koichi Kato</name><name sortKey="Kawaoka, Yoshihiro" sort="Kawaoka, Yoshihiro" uniqKey="Kawaoka Y" first="Yoshihiro" last="Kawaoka">Yoshihiro Kawaoka</name><name sortKey="Kawaoka, Yoshihiro" sort="Kawaoka, Yoshihiro" uniqKey="Kawaoka Y" first="Yoshihiro" last="Kawaoka">Yoshihiro Kawaoka</name><name sortKey="Kida, Hiroshi" sort="Kida, Hiroshi" uniqKey="Kida H" first="Hiroshi" last="Kida">Hiroshi Kida</name><name sortKey="Miyamoto, Daisei" sort="Miyamoto, Daisei" uniqKey="Miyamoto D" first="Daisei" last="Miyamoto">Daisei Miyamoto</name><name sortKey="Miyamoto, Daisei" sort="Miyamoto, Daisei" uniqKey="Miyamoto D" first="Daisei" last="Miyamoto">Daisei Miyamoto</name><name sortKey="Otsuki, Koichi" sort="Otsuki, Koichi" uniqKey="Otsuki K" first="Koichi" last="Otsuki">Koichi Otsuki</name><name sortKey="Suzuki, Takashi" sort="Suzuki, Takashi" uniqKey="Suzuki T" first="Takashi" last="Suzuki">Takashi Suzuki</name><name sortKey="Suzuki, Takashi" sort="Suzuki, Takashi" uniqKey="Suzuki T" first="Takashi" last="Suzuki">Takashi Suzuki</name><name sortKey="Suzuki, Yasuo" sort="Suzuki, Yasuo" uniqKey="Suzuki Y" first="Yasuo" last="Suzuki">Yasuo Suzuki</name><name sortKey="Suzuki, Yasuo" sort="Suzuki, Yasuo" uniqKey="Suzuki Y" first="Yasuo" last="Suzuki">Yasuo Suzuki</name><name sortKey="Suzuki, Yasuo" sort="Suzuki, Yasuo" uniqKey="Suzuki Y" first="Yasuo" last="Suzuki">Yasuo Suzuki</name><name sortKey="Suzuki, Yasuo" sort="Suzuki, Yasuo" uniqKey="Suzuki Y" first="Yasuo" last="Suzuki">Yasuo Suzuki</name><name sortKey="Takahashi, Noriko" sort="Takahashi, Noriko" uniqKey="Takahashi N" first="Noriko" last="Takahashi">Noriko Takahashi</name><name sortKey="Takahashi, Noriko" sort="Takahashi, Noriko" uniqKey="Takahashi N" first="Noriko" last="Takahashi">Noriko Takahashi</name><name sortKey="Takahashi, Noriko" sort="Takahashi, Noriko" uniqKey="Takahashi N" first="Noriko" last="Takahashi">Noriko Takahashi</name><name sortKey="Takahashi, Tadanobu" sort="Takahashi, Tadanobu" uniqKey="Takahashi T" first="Tadanobu" last="Takahashi">Tadanobu Takahashi</name><name sortKey="Takahashi, Tadanobu" sort="Takahashi, Tadanobu" uniqKey="Takahashi T" first="Tadanobu" last="Takahashi">Tadanobu Takahashi</name><name sortKey="Yagi, Hirokazu" sort="Yagi, Hirokazu" uniqKey="Yagi H" first="Hirokazu" last="Yagi">Hirokazu Yagi</name><name sortKey="Yagi, Hirokazu" sort="Yagi, Hirokazu" uniqKey="Yagi H" first="Hirokazu" last="Yagi">Hirokazu Yagi</name><name sortKey="Yi, Shuang Qin" sort="Yi, Shuang Qin" uniqKey="Yi S" first="Shuang-Qin" last="Yi">Shuang-Qin Yi</name></country><country name="États-Unis"><region name="Wisconsin"><name sortKey="Kawaoka, Yoshihiro" sort="Kawaoka, Yoshihiro" uniqKey="Kawaoka Y" first="Yoshihiro" last="Kawaoka">Yoshihiro Kawaoka</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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